The cannabis plant harbors a myriad of compounds with untapped therapeutic potential. Beyond the well-known THC and CBD, emerging research is spotlighting alternative cannabinoids like CBG (Cannabigerol) and CBN (Cannabinol), promising new horizons in healthcare and medicine.

The Continued Rise of CBD, CBG and CBN

The Penn State study on CBD and CBG presented groundbreaking findings regarding bone healing and pain management, suggesting these cannabinoids could serve as alternatives to NSAIDs, which may hinder healing processes. The research emphasized CBD and CBG’s roles in increasing bone progenitor cells and enhancing mineralization for improved bone recovery. The study observed that CBD and CBG could promote the growth of bone cells and enhance mineral absorption in bones, crucial steps in the healing process. This comprehensive study sets a foundation for further exploration into cannabinoids’ medicinal properties, especially in orthopedics.

​Spotlight on CBG: The Precursor with Promise

Cannabigerol (CBG) is gaining attention in the medical research community due to its potential health benefits, distinct from other more well-known cannabinoids like THC and CBD. Originating from cannabigerolic acid (CBGA), CBG is often referred to as the “mother” or “stem cell” of cannabinoids, as it is the precursor from which other cannabinoids are synthesized.

Recent studies, particularly from McMaster University, highlight CBG’s significant antibiotic properties. This research, conducted in mice, showcases CBG’s effectiveness against MRSA strains, which are notorious for their resistance to conventional antibiotics. The findings are promising, indicating CBG’s potential as a novel antibacterial agent. The study also notes CBG’s ability to prevent bacterial biofilms, a key contributor to persistent infections. This aligns with the broader scope of cannabis research, pointing towards its therapeutic potentials beyond the psychoactive components traditionally associated with the plant

The medical benefits associated with CBG are currently under investigation, with preliminary studies suggesting several potential therapeutic applications:

1. Anti-inflammatory properties: CBG may help in reducing inflammation, making it potentially useful for conditions such as inflammatory bowel disease.
2. Neuroprotective effects: Early research suggests CBG could have protective effects on the nervous system, which may benefit individuals with diseases like Huntington’s.
3. Antibacterial properties: Some studies indicate that CBG possesses antibacterial properties, particularly against MRSA bacterial strains resistant to traditional antibiotics.
4. Glaucoma treatment: CBG has been found to reduce intraocular pressure, making it a candidate for the treatment of glaucoma.
5. Cancer treatment: There is preliminary evidence to suggest that CBG might have anti-tumoral properties, potentially inhibiting the growth of certain types of cancer cells.
6. Appetite stimulation: Unlike CBD, which can suppress appetite, CBG has been shown to stimulate appetite, suggesting potential benefits for patients suffering from conditions like cancer or HIV/AIDS that result in loss of appetite.
7. Pain relief: While not as extensively studied as other properties, CBG might contribute to pain management by interacting with the body’s endocannabinoid system.

It is important to note that while these findings are promising, most of the research on CBG is still preliminary and has been conducted in preclinical settings or on animal models. Clinical studies in humans are necessary to fully understand the therapeutic potential and safety profile of CBG.

Despite being the chemical parent of THC and CBD, CBG is present in lower concentrations in mature plants. However, it’s gaining attention for its energizing and anti-inflammatory properties, with research hinting at its utility in fighting fatigue, reducing anxiety, and possibly countering cancerous cells​.

As the scientific community continues to explore CBG, more definitive conclusions and applications may emerge, contributing to a broader understanding of its role within medical treatment paradigms.

​​

CBN: The Sleep-Inducing Byproduct

CBN, a derivative from THC’s breakdown, emerges as a contender in the sleep aid sphere without the psychoactive intensity. This transformation piques interest for those seeking rest without the high typical of THC. CBN’s mild, non-intoxicating nature is coupled with potential sedative synergies when paired with THC, but misconceptions about its sole effects persist, largely attributed to terpene influences in aged cannabis rather than CBN directly.

Salk Institute for biological studies, a non- profit organization founded by Jonas Salk, who introduced the first safe Polio vaccine  discovered that cannabinol (CBN) can protect nerve cells from oxidative damage, which contributes to cell death and is a major factor in neurodegenerative diseases like Alzheimer’s. They found CBN preserves mitochondrial function, crucial for cell health, potentially offering new treatment avenues for age-related disorders. This study suggests CBN’s significant therapeutic potential, particularly for neurodegenerative diseases, without psychoactive effects​. 

Emerging research points to multiple possible advantages of CBN:

1. Antibacterial: Effective against antibiotic-resistant MRSA, highlighting CBN’s role in combating stubborn infections.
2. Neuroprotective: Shows potential in animal models for disorders like ALS and Alzheimer’s disease, suggesting a frontier for neurodegenerative disease management.
3. Appetite Enhancement: Unlike CBD, CBN may promote eating, aiding individuals with medical conditions that lower appetite.
4. Anti-inflammatory: Its properties could address conditions such as rheumatoid arthritis by reducing inflammation.
5. Glaucoma Management: Preliminary results indicate potential in lowering intraocular pressure, a significant glaucoma risk.
6. Bone Health: Research hints at benefits in bone regeneration and repair, offering hope for osteoporosis and similar conditions.
7. Pain Reduction: Influences pain perception pathways, particularly those responsive to capsaicin, which may alleviate discomfort.

While promising, current studies primarily involve animal subjects and are at an initial stage. Extensive human trials are required to substantiate these benefits and fully understand CBN’s impact on health. This gap underscores the necessity for further inquiry to clarify its role in therapeutic applications.

Broadening the Cannabis Spectrum

The journey into the depths of cannabis’s lesser-known compounds, like CBG and CBN, is just beginning. As we delve deeper, the potential for new treatments and understanding of plant-based medicine expands, marking the dawn of a new era in therapeutic discovery. For a more in-depth exploration and the latest research findings, readers are encouraged to review the studies from institutions like the University of Michigan and Penn State, which provide valuable insights into the evolving landscape of cannabis compounds.

Vallejo Relief Center offers top-quality products with these healing cannabis compounds. Visit us today!